糖原合成酶激酶-3 (Glycogen synthase kinase-3, GSK-3)是一个多功能的丝氨酸/苏氨酸蛋白激酶,不仅参与肝糖代谢过程,而且还参与Wnt和Hedgehog信号通路,通过磷酸化多种底物蛋白来调节 细胞的生理过程。GSK-3抑制剂作为目前倍受关注的小分子抑制剂,对治疗神经退化性疾病,癌症具有潜在疗效。
GSK-3 抑制剂
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| 目录 |
产品名称 |
产品描述 |
| S1263 |
CHIR-99021 (CT99021) |
CHIR 99021是最有效和特定的GSK3抑制剂，IC50为40 nM。 |
| S1075 |
SB 216763 |
SB 216763 inhibited human GSK-3α with IC50s of 34 nM. |
| S2386 |
Indirubin |
Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM. |
| S1590 |
TWS119 |
TWS119 is a glycogen synthase kinase-3β inhibitor with an IC50 of 30 nM. |
| S2729 |
SB 415286 |
SB 415286 is a potent and selective cell-permeable, ATP-competitive GSK3α inhibitor with an IC50 and a Ki of 78 and 31 nM, respectively. |