丝氨酸/苏氨酸激酶AKT, 又名蛋白激酶B (Protein Kinase B, PKB)，是众多生长因子的具有酪氨酸激酶作用的受体（RTK）后的细胞信号传导通路中极为重要的激酶。其家族有三个异构体：Akt1(PKBα)，Akt2(PKBβ)，Akt3(PKBγ)。
AKT 抑制剂
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| 目录 |
产品名称 |
产品描述 |
| S1078 |
MK-2206 dihydrochloride |
MK-2206高度选择性地抑制Akt,作用于Akt1, Akt2和Akt3 时IC50 分别为8, 12 和65 nM。 |
| S1037 |
Perifosine |
Perifosine抑制Akt，抗肿瘤增生，IC50为0.6–8.9 µM。 |
| S1113 |
GSK690693 |
GSK690693 is a pan-Akt kinase inhibitor,IC50 of Akt 1, 2, and 3 at 2, 13, and 9 nM respectively. |
| S1558 |
AT7867 |
AT7867 is an orally bioavailable inhibitor of AKT and p70 S6 kinase inhibitor with an IC50 of 17 nM. |
| S2635 |
CCT128930 |
CCT128930 is a novel potent ATP-competitive, AKT inhibitor with an IC50 of 6 nM. |
| S1556 |
PHT-427 |
PHT-427 is a dual Akt and PDPK1 inhibitor that affects downstream targetsamong sensitive but not resistant cells and tumor xenografts. |
| S2238 |
Palomid 529 (P529) |
Palomid 529 (P529) is a novel PI3K/Akt/mTOR inhibitor with a GI50 of <35 μM in the NCI-60 cell lines panel. |
| S2732 |
Triciribine phosphate (NSC-280594) |
Triciribine phosphate (NSC-280594) is a novel potent, small-molecule Akt inhibitor. |
| S2670 |
A-674563 |
A-674563 is a potent selective protein kinase B/Akt inhibitor with an IC50 of 14 nM. |
| S2310 |
Honokiol |
Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris. |
| S1117 |
Triciribine |
Akt inhibitor |