| 中文名: |
2-甲氧基-N-[3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺;CP-724714 |
| 中文别名: |
CP 724714; 2-甲氧基-N-[3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺; |
| 英文名称： |
CP-724,714 |
| 英文别名： |
(E)-2-methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide;2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide |
| CAS No.: |
537705-08-1 |
| 分子式: |
C27H27N5O3 |
| 分子量: |
469.53 |
| 性状: |
属性
| 溶解性 |
<li>DMSO 94 mg/mL </li><li>Water <1 mg/mL </li><li class="b_bottom">Ethanol 94 mg/mL </li> |
| 存贮条件 |
储存温度-20°C |
描述
| 产品介绍 |
CP-724714是一种有效的，选择性的HER2/ErbB2抑制剂，IC50为10 nM，比作用于EGFR， InsR， IRG-1R， PDGFR， VEGFR2， Abl， Src， c-Met等选择性高640多倍。 |
| 用途 |
Marked selectively against EGFR and potently reduces the EGF-induced autophosphorylation. |
| 生化机理 |
CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc. |
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| 储存: |
储存温度-20°C |
| 安全术语: |
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| 风险术语: |
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| 危险品标志: |
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| 危险品运输编号: |
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| 用途: |
CP-724,714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor under development for the treatment of advanced HER2-overexpressing cancers. [1]
[1] Jani JP et al. Cancer Res. 2007 Oct 15;67(20):9887-93
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