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Pimobendan(Vetmedin) is a Ca(2+) sensitizer with an IC50 of 26 μM and a selective phosphodiesterase III inhibitor with an IC50 of <1 μM. [1] The inhibitory effects of pimobendan on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells. Pimobendan decreased the catecholamine secretion (IC(50)=29.5 μM) elicited by carbachol, an agonist at nicotinic acetylcholine receptors, but not that elicited by veratridine, an activator of voltage-dependent Na(+) channels, or by high K(+), an activator of voltage-dependent Ca(2+) channels. Pimobendan also inhibited carbachol-induced influx of Na(+) (IC(50)=25.9 μM) and Ca(2+) (IC(50)=26.0 μM), but not veratridine-induced Na(+) influx or high K(+)-induced Ca(2+) influx. [2]
[1] http://en.wikipedia.org/wiki/Pimobendan
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