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 CHEMICAL ENGINEERING JOURNAL（IF=15.1)
文献引用产品：
| 货号 |
产品名称 |
CAS |
规格 |
| B20182 |
橙皮苷 |
520-26-3 |
分析标准品,
HPLC≥98% |
摘要：Rheumatoid arthritis is an autoimmune disease characterized by inflammatory cell infiltration, neovascularization in the synovial tissue, and progressive joint destruction. The immunomodulatory drug lenalidomide and anti-inflammatory anti-oxidant hesperidin show therapeutic potential against the disease as two complementary drugs, but they also show poor oral bioavailability and solubility as well as a short time in circulation. To overcome these disadvantages, the two drugs were loaded into polymeric micelles in their native forms and also, they were conjugated to polyethylene glycol to create acid-activated prodrugs. Lastly, the micelles alone or with the prodrugs were formulated into an injectable hydrogel. Of all formulations, the hydrogel containing micelles and prodrugs led to the greatest drug uptake by Raw264.7 macrophages in culture and inhibition of angiogenesis in a chick chorioallantoic membrane assay. In rats with collagen-induced arthritis, the hydrogel released the two drugs in a sustained manner, preferentially in joints with acidic pH. They dampened inflammatory responses, mitigating bone injury. This biocompatible, pH-responsive formulation based on two complementary drugs may provide a new strategy for treating rheumatoid arthritis.
https://www.sciencedirect.com/science/article/pii/S1385894723050015
 CHEMICAL ENGINEERING JOURNAL（IF=15.1)
文献引用产品：
| 货号 |
产品名称 |
CAS |
规格 |
| B25328 |
D-纤维二糖 |
528-50-7 |
分析标准品,
HPLC≥98% |
摘要：As a crucial bio-based platform chemical, the production of 5-hydroxymethylfurfural (HMF) from the abundant substrate cellulose has garnered significant attention. However, tedious reaction steps are inevitable because of the complex tandem conversions of dissolution, hydrolysis, and dehydration. Furthermore, due to the ultralow solubility of cellulose, harsh reaction conditions are inevitable, which can exacerbate HMF degradation. To this end, we investigated the structural changes in microcrystalline cellulose (MCC) after its dissolution and regeneration in various dimethyl sulfoxide (DMSO)/deep eutectic solvents (DESs) to clarify the mechanisms underlying its dissolution. The results revealed that the highly crystalline cellulose I in MCC was converted into amorphous cellulose II after treatment with DMSO/tetraethylammonium chloride (TEAC), which led to the complete dissolution of MCC. Accordingly, a dissolution-catalysis coupling reaction strategy was proposed for converting MCC to HMF via a one-pot method in DMSO/TEAC, simultaneously reducing the number of steps necessary for the reaction and achieving mild reaction conditions. In addition, the pathway for the one-pot reaction was clarified by analyzing the intermediate yields. The combination of AlCl3 as a catalyst and DMSO/TEAC resulted in a notable MCC conversion of 93.3 wt% and a high HMF yield of 53.1%. Remarkably, the reaction conditions employed in this study (130 °C, 1 h) were milder in terms of shorter reaction times and lower temperatures than those reported in most current literature. This was attributed to the complete dissolution of MCC resulting from decrystallization. Therefore, the proposed reaction strategy enabled the efficient production of HMF from cellulose.
文献链接：
https://www.sciencedirect.com/science/article/abs/pii/S1385894723049483
 CHEMICAL ENGINEERING JOURNAL（IF=15.1)
| 货号 |
产品名称 |
CAS |
规格 |
| B20782 |
绿原酸 |
327-97-9 |
分析标准品,
HPLC≥98% |
摘要：Compartmentalized delivery systems can achieve simultaneous encapsulation of multiple guest cargos in independent spaces and are becoming a topic of tremendous interest in medical and food disciplines. Herein, we reported a top-down assisted bottom-up approach to fabricate stable multi-chamber colloid (MCC) particles by using ferritin nanocages, which can be applied for compartmentalized loading of incompatible guest cargos. Our results demonstrated that the size of MCC particles can be regulated by controlling synthetic parameters. The primary amines of arginine and lysine residues distributed over the exterior surface and subunit-subunit interfaces of ferritin are responsible for the formation of covalent crosslinking bridges, thus, stabilizing the compartmentalized structure of MCC particles with pH value even lower to ∼2.0. Remarkably, by choosing Nile-red and FITC as guest cargos, LSCM images clearly demonstrated that Nile-red and FITC are compartmentalized encapsulated within each MCC particle, illustrating the compartmentalized loading capacity of MCC particles. Moreover, the MCC structures feature highly sealed independent compartments. When two incompatible guest cargos, chlorogenic acid (ChA) and iron core nanoparticles, are compartmentalized loaded within MCC particles, the protein shell barrier can efficiently hinder their physical contact and inhabit the redox reaction. Conversely, upon structural destruction, ChA and iron core nanoparticles are co-released and the redox reaction can be triggered, ultimately leading to the controlled release of ferrous ions for iron supplementation. This study provided a facile strategy for the construction of stable compartmentalized delivery systems, which have great potential for co-delivery of incompatible molecules in food and medical disciplines.
文献链接：
https://www.sciencedirect.com/science/article/pii/S1385894723047605
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