基本信息:
中文名称 氯沙坦钾
中文别名 2-丁基-4-氯-1-([2''-(1H-四唑-5)(1,1''''-联苯)-4-基]甲基)-1H-咪唑-5-甲醇单钾盐;科素亚钾盐;氯沙坦钾盐;洛沙坦钾;2-丁基-4-氯-5-(羟甲基)-[[2''-(1H-四氮唑-5-基)联苯-4-基]甲基]咪唑钾;
英文名称 Losartan potassium
英文别名 thanolpotassium;COZAAR;potassium (2-butyl-4-chloro-1-{[2''-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanolate;Losartan (potassium);Losartan Potassium;LOSARTAN, POTASSIUM SALT;dupont753;DUP 753;Losartan Potassium (DuP 753);2-BUTYL-4-CHLORO-1-[[2''-(1H-TETRAZOL-5-YL)[1,1''-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL MONOPOTASSIUM SALT;mk-0954;Losartan (potassium salt);Aradois;LOSARTAN POTASSIUM(SUBJECT TO PATENT FREE);LOSARTAN POTASSIUM, EP STAANDARD;MK-95;MK 954;LOSARTANPOTASSIUM;Losartanpatassium;{2-BUTYL-5-CHLORO-3-[2''-(1H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-3H-IMIDAZOL-4-YL}-METHANOL POTASSIUM SALT;
CAS号 124750-99-8
合成路线:
1.通过2-(四唑-5-基)苯硼酸和1-(4-溴苄基)-2-丁基-4-氯-1H-咪唑-5-甲醇合成氯沙坦钾,收率约76%;
2.通过洛沙坦合成氯沙坦钾,收率约92%;
中华试剂网提醒:合成路线仅供参考