| 生化机理 |
AZD6482 inhibits PI3Kα, β, γ, and δ, with IC50 of 21 nM to 1.4 μM. AZD6482 is an antiplatelet agent; it blocks platelet activation adhesion/aggregation and promotes platelet disaggregation in an assay of washed platelet aggregation (WPA), with an IC50 value of 6 nM. Furthermore, by targeting PI3Kβ, AZD6482 specifically inhibits thrombosis without interfering with normal haemostasis. |